Notch signalling cascade and proinflammatory mediators in peri-implant lesions with different RANKL/OPG ratios-An observational study.

Ana Djinic Krasavcevic,Nadja Nikolic,Iva Milinkovic,Jelena Carkic,Marija Jezdic,Sasha Jankovic,Zoran Aleksic,Jelena Milasin

Journal of periodontal research（2023）

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摘要

Notch2 upregulation in RANKL-predominant PM lesions could be an important contributor to alveolar bone resorption and represent a predictor of PM to PI transition. Similarly, the overexpression of IL-1β and IL-6 might provide an osteoclastogenic environment in PI RANKL-predominant lesions.

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Notch signaling,gene expression,peri-implant mucositis,peri-implantitis

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