Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ.

Caroline Kardeby,Alice Evans,Joana Campos,Afraa Moosa Al-Wahaibi,Christopher W. Smith,Alexandre Slater,Eleyna M. Martin,Sonia Severin,Alexander Brill,Gunnar Pejler,Yi Sun,Steve P. Watson

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

Our findings reveal that PEAR1 is a receptor for heparin and HPGM and that PI3Kβ is a key signaling molecule downstream of PEAR1 in platelets. These findings may have important implications for our understanding of the role of PEAR1 in cardiovascular disease.

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关键词

Fucoidan,glycosaminoglycan,polysaccharides,signal transduction,sulfates

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