The impact of ADRB2 polymorphisms on immune responses and norepinephrine-induced immunosuppression.

Roeland F Stolk,Niklas Bruse,Rob ter Horst,Aron Jansen,Isis Ricaño Ponce,Jelle Gerretsen,Johannes van der Hoeven,Vinod Kumar,Mihai G Netea,Peter Pickkers,Matthijs Kox

Journal of leukocyte biology（2023）

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摘要

Common nonsynonymous variants in the ADRB2 gene influence neither ex vivo cytokine production or norepinephrine-mediated immunosuppression nor the systemic in vivo inflammatory response induced by lipopolysaccharide administration in healthy volunteers.

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关键词

ADRB2 SNPs,cytokines‌,endotoxemia,norepinephrine

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