Evaluation of clinical harm associated with Omicron hospital-onset COVID-19 infection

•We reviewed outcomes for 129 patients with Omicron hospital-onset COVID-19 infection.•86 (66.7%) were asymptomatic; 15 (11.6%) had increased length of stay.•11 (8.5%) required supplemental oxygen, two (1.6%) required ICU or HDU.•3 (2.3%) had COVID-19 as a direct cause of death, and 4 (3.1%) where COVID-19 contributed.•No associations between harm and age, vaccination, or vulnerability were found.