The cathepsin-S/protease-activated receptor-(PAR)-2 axis drives chronic allograft vasculopathy and is a molecular target for therapeutic intervention

Martin Ryll,Yutian Lei,Michael N Thomas,Mingming Li,Bernhard Renz,Ulrich Wirth,Florian Kühn,Alexandr Bazhin,Jens Werner,Hans-Joachim Anders,Joachim Andrassy

Transplant Immunology（2023）

引用 0|浏览11

暂无评分

摘要

In conclusion, our data indicate that inhibiting CatS and PAR-2 deficiency led to a marked reduction of neointima formation and associated inflammation in a murine heterotopic model for allograft vasculopathy.

查看译文

关键词

Transplantation,Rejection,Allograft vasculopathy,Cathepsin S,Proteinase-activated receptor-2

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要