The role of lymphoid tissue SPARC in the pathogenesis and response to treatment of multiple myeloma.

Nesreen Amer Ramadan Aly,Samia Rizk,Azza Aboul Enein, Nermeen El Desoukey,Hamdy Zawam, Manzoor Ahmed,Mohey Eldin El Shikh,Costantino Pitzalis

Frontiers in oncology（2022）

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摘要

FDC-SPARC inhibits several myelomagenic gene expression and inversely correlates with PC infiltration and MM progression. Therapeutic induction of SPARC expression through combinations of the current MM drugs, repositioning of non-MM drugs, or novel drug discovery could pave the way to better control MM in clinically severe and drug-resistant patients.

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关键词

SPARC,bone marrow,follicular dendritic cells,germinal center reactions,lymphoid neoplasia,multiple myeloma,tumor microenvironments

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