CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification.

Zhe Gong,Kefan Wang,Junxin Chen,Jinjin Zhu,Zhenhua Feng,Chenxin Song,Zheyuan Zhang,Haoming Wang,Shunwu Fan,Shuying Shen,Xiangqian Fang

Clinical and translational medicine（2023）

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摘要

Our results revealed a significant role of CircZSWIM6 in age-related OA by regulating ECM metabolism and AMPK-associated energy metabolism. We highlight the CircZSWIM6-RPS14-PCK1-AMPK axis is a potential biomarker for OA.

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关键词

AMPK,CircZSWIM6,RPS14,metabolism,osteoarthritis,senescence

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