Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase.

Yuanfeng Zhu,Xiaoli Chen,Yongling Lu,Lin Xia,Shijun Fan,Qianying Huang,Xin Liu,Xi Peng

Burns & trauma（2022）

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摘要

Glutamine mitigates murine burn sepsis by essentially supporting macrophage M2 polarization, with a mechanism involving the repression of the SIRT5-mediated desuccinylation of pyruvate dehydrogenase that replenishes OXPHOS and sustains M2 macrophages.

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关键词

Burn, Sepsis,Desuccinylation,Glutamine,Macrophages polarization,PDH,SIRT5

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