Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages.

Mingxuan Zhu,Liangliang Bai,Xiaoxia Liu,Shaoyong Peng,Yumo Xie, Hong Bai,Huichuan Yu,Xiaolin Wang,Ping Yuan, Rui Ma,Jinxin Lin,Linping Wu,Meijin Huang,Yingjie Li,Yanxin Luo

Journal for immunotherapy of cancer（2022）

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摘要

Our findings revealed that CSF1R is a novel identified dependence receptor silenced in CRC. The silence abalienates its ligands to stimulate CSF1R expressed on M2 TAMs, which is an appealing therapeutic target for M2 TAM depletion and CRC treatment.

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关键词

gastrointestinal neoplasms,immunotherapy,macrophages,receptors, immunologic,tumor microenvironment

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