Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells.

Jui-Ting Chang,Yao-Jen Liang,Jyh-Gang Leu

Journal of the Chinese Medical Association : JCMA（2023）

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摘要

PPARδ agonists increase GLP-1R expression on RMC in the presence of AGE. PPARδ agonists also attenuate AGE-induced upregulated RAGE expression and downregulated cell viability. The effect of PPARδ agonists needs the cooperation of GLP-1R activation.

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关键词

Advanced glycation end products,Glucagon,like peptide,1 receptor,Peroxisome proliferator,activated receptors delta,Rat mesangial cell

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