Novel view of arrhythmogenic cardiomyopathy as a “multicellular disease” affecting cardiac sympathetic innervation
Journal of Molecular and Cellular Cardiology(2022)
摘要
Arrhythmogenic Cardiomyopathy (AC) is an incurable familial cardiac disease, mainly due to mutations in desmosomal genes, accounting for most cases of stress-related arrhythmic sudden death, in the young and athletes. AC hearts display cardiomyocyte (CM) death and diffuse fibro-fatty lesions, which compromise cardiac contractile performance and generate the substrate for arrhythmias. Correlation between physical/emotional stresses and arrhythmias incriminates sympathetic neurons (SNs), which may be the sought-after killers in disguise.
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关键词
arrhythmogenic,cardiac,innervation,multicellular disease”
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