Identification of novel benzimidazole-based small molecule targeting dual targets Tankyrase and Bcl2 to induce apoptosis in Colon cancer

Yarabahally R Girish,BM Anil Kumar,Kothanahally S. Sharath Kumar,Vivek K Hamse,Prashantha K,MS Sudhanva, Shobith R

Journal of Molecular Structure（2022）

引用 8|浏览3

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摘要

•Compound 5d, induces potent apoptosis in various cancer cells.•Compound 5d, specifically targets dual targets, Tankyrase and Bcl2 to induce apoptosis.•Compound 5d, decreases the colony forming capabilities•Docking and molecular dynamic simulations confirms efficient binding of Compound 5d to Tankyrase and Bcl2.

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关键词

Colon cancer,Medicinal Chemistry,Apoptosis,Small molecule

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