Clozapine-induced diarrhoea: A case report of an unusual adverse reaction

Clozapine has proven efficacy in treatment-resistant schizophrenia, though there have been reports of untoward reactions to its use, including cases of rare side effects. The authors here describe a case of an unusual constellation of symptoms, predominantly diarrhoea, that consistently occurred over 3 attempts to treat a patient with clozapine. We conclude with a recommendation that clinicians need to be aware that new-onset diarrhoea may be an adverse reaction to clozapine.