Butyrate impeded the conscription of MDSCs to reduce CAC formation by blocking the TLR2 signaling pathway

Tengfei Xiao,Mingzhong Sun,Yi Chang,Jingjing Kang,Chuanxiang Zhao, Rong Zhu,Hongmei Chen, Yetao Qiang

Journal of Functional Foods（2022）

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摘要

•Butyrate alleviated CAC development.•Butyrate inhibited proliferation and promoted apoptosis of CAC cells.•Butyrate inhibited the levels of MDSCs and cytokine in the TME.•Butyrate inhibited the activation of TLR2 signaling pathway.•Butyrate inhibited DSS-induced inflammation by TLR2 in Caco-2 cells.

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关键词

Butyrate,Colitis-associated colorectal cancer,Tumor microenvironment,Myeloid-derived suppressor cells,TLR2

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