Genetic Effect on Body Mass Index and Cardiovascular Disease Across Generations.

Chloé Sarnowski,Matthew P Conomos,Ramachandran S Vasan,James B Meigs,Josée Dupuis,Ching-Ti Liu,Aaron Leong

Circulation. Genomic and precision medicine（2023）

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摘要

The significant GRS-birth year interactions indicate that common genetic variants have larger effects on middle-age BMI and CVD risk in people born more recently. These findings suggest that the increasingly obesogenic environment may amplify the impact of genetics on the risk of obesity and possibly its cardiovascular consequences.

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关键词

body mass index,cardiovascular disease,coronary artery disease,lipoprotein,obesity

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