Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver.

Saleh Y Alabbas,Rabina Giri,Iulia Oancea,Julie Davies, Veronika Schreibner,Timothy H Florin,Jakob Begun

Journal of gastroenterology and hepatology（2023）

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摘要

This study identifies novel roles for APAP in causing colitis, the amplification of APAP-liver toxicity where there is underlying colitis, and involvement of immune memory in APAP-toxicity. The latter could be key for decoding the poorly understood but important clinical entity of chronic APAP liver failure.

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acetaminophen,colon,gut-liver axis,immunology,liver injury,paracetamol

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