Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD.

Alen Faiz,Stelios Pavlidis,Chih-Hsi Kuo,Anthony Rowe,Pieter S Hiemstra,Wim Timens,Marijn Berg,Marissa Wisman,Yi-Ke Guo,Ratko Djukanović,Peter Sterk,Kerstin B Meyer,Martijn C Nawijn,Ian Adcock,Kian Fan Chung,Maarten van den Berge

Thorax（2023）

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摘要

Sputum-derived transcriptomic signatures from an asthma cohort can be recapitulated in bronchial biopsies of patients with COPD and identified a signature of airway mast cells as a predictor of corticosteroid responsiveness.

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关键词

COPD pathology,airway epithelium,oxidative stress

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