Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS

HomeCirculation: Arrhythmia and ElectrophysiologyVol. 16, No. 1Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextCharacteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS Anat Milman, MD, PhD, Avi Sabbag, MD, Giulio Conte, MD, PhD, Pieter G. Postema, MD, PhD., Antoine Andorin, MD, Jean-Baptiste Gourraud, MD, PhD, Frederic Sacher, MD, Philippe Mabo, MD, Sung-Hwan Kim, MD, Shingo Maeda, MD, PhD, Yoshihide Takahashi, MD, PhD, Tsukasa Kamakura, MD, PhD, Takeshi Aiba, MD, PhD, Jimmy JM Juang, MD, PhD, Yoav Michowitz, MD, Eran Leshem, MD, Yuka Mizusawa, MD, Elena Arbelo, MD, PhD, Zhengrong Huang, MD, PhD, Isabelle Denjoy, MD, Carla Giustetto, MD, Yanushi D. Wijeyeratne, MD, Andrea Mazzanti, MD, Ramon Brugada, MD, PhD, Ruben Casado-Arroyo, MD, PhD, Jean Champagne, MD, Leonardo Calo, MD, Georgia Sarquella-Brugada, MD, PhD, Jacob Tfelt-Hansen, MD, DMSc, Silvia G. Priori, MD, PhD, Masahiko Takagi, MD, PhD, Christian Veltmann, MD, Pietro Delise, MD, Domenico Corrado, MD, PhD, Elijah R. Behr, MD, Fiorenzo Gaita, MD, Gan-Xin Yan, MD, PhD, Josep Brugada, MD, PhD, Antoine Leenhardt, MD, Arthur A.M. Wilde, MD, PhD, Pedro Brugada, MD, PhD, Kengo F. Kusano, MD, PhD, Kenzo Hirao, MD, PhD, Gi-Byoung Nam, MD, PhD, Vincent Probst, MD, PhD and Bernard Belhassen, MD Anat MilmanAnat Milman Correspondence to: Anat Milman, MD PhD, Davidai Arrhythmia Center, Leviev Heart Center Sheba Medical Center, Tel Hashomer 5265601, Israel. Email E-mail Address: [email protected] https://orcid.org/0000-0002-8551-4101 Leviev Heart Institute, The Chaim Sheba Medical Centre, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (A.M., A.S., E.L.). Search for more papers by this author , Avi SabbagAvi Sabbag https://orcid.org/0000-0003-4295-6679 Leviev Heart Institute, The Chaim Sheba Medical Centre, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (A.M., A.S., E.L.). Search for more papers by this author , Giulio ConteGiulio Conte https://orcid.org/0000-0003-2248-3456 Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium (G.C., P.B.). Search for more papers by this author , Pieter G. PostemaPieter G. Postema https://orcid.org/0000-0003-2863-9159 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Amsterdam UMC, University of Amsterdam, Heart Centre and Department of Clinical and Experimental Cardiology, Amsterdam, the Netherlands (P.G.P., Y.M., A.A.M.W.). Search for more papers by this author , Antoine AndorinAntoine Andorin https://orcid.org/0000-0001-6848-5452 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Service de Cardiologie, CHU de Nantes (A.A., J.B.G., V.P.). Search for more papers by this author , Jean-Baptiste GourraudJean-Baptiste Gourraud https://orcid.org/0000-0002-6961-2131 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Service de Cardiologie, CHU de Nantes (A.A., J.B.G., V.P.). Search for more papers by this author , Frederic SacherFrederic Sacher https://orcid.org/0000-0001-8348-9320 Hôpital Cardiologique du Haut-Lévêque and University Bordeaux, LIRYC Instituteitute (F.S.). Search for more papers by this author , Philippe MaboPhilippe Mabo Cardiology and Vascular Disease Division, Rennes University Health Centre, Rennes, France (P.M.). Search for more papers by this author , Sung-Hwan KimSung-Hwan Kim https://orcid.org/0000-0001-6805-0416 Division of Cardiology, College of Medicine, The Catholic University of Korea, Seoul, Korea (S.-H.K.). Search for more papers by this author , Shingo MaedaShingo Maeda https://orcid.org/0000-0001-6964-0653 Heart Rhythm Centre, Tokyo Medical and Dental University, Tokyo (S.M., Y.T., K.H.). Search for more papers by this author , Yoshihide TakahashiYoshihide Takahashi https://orcid.org/0000-0003-0335-996X Heart Rhythm Centre, Tokyo Medical and Dental University, Tokyo (S.M., Y.T., K.H.). Search for more papers by this author , Tsukasa KamakuraTsukasa Kamakura https://orcid.org/0000-0003-2964-2544 Division of Arrhythmia & EleCentreophysiology, National Cerebral & Cardiovascular Centre, Osaka, Japan (T.K., T.A.). Search for more papers by this author , Takeshi AibaTakeshi Aiba https://orcid.org/0000-0003-1779-7282 Division of Arrhythmia & EleCentreophysiology, National Cerebral & Cardiovascular Centre, Osaka, Japan (T.K., T.A.). Search for more papers by this author , Jimmy JM JuangJimmy JM Juang https://orcid.org/0000-0003-4767-7636 Cardiovascular Centre and Division of Cardiology, National Taiwan University Hospital and University College of Medicine, Taipei, Taiwan (J.J.M.J.). Search for more papers by this author , Yoav MichowitzYoav Michowitz https://orcid.org/0000-0002-5665-3735 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Cardiology Department, Shaare Zedek Hospital, Affiliated to the Faculty of Medicine, Hebrew University, Jerusalem, Israel (Y.M.). Search for more papers by this author , Eran LeshemEran Leshem https://orcid.org/0000-0002-8896-460X Leviev Heart Institute, The Chaim Sheba Medical Centre, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (A.M., A.S., E.L.). Search for more papers by this author , Yuka MizusawaYuka Mizusawa https://orcid.org/0000-0003-1858-0923 Amsterdam UMC, University of Amsterdam, Heart Centre and Department of Clinical and Experimental Cardiology, Amsterdam, the Netherlands (P.G.P., Y.M., A.A.M.W.). Search for more papers by this author , Elena ArbeloElena Arbelo https://orcid.org/0000-0003-0424-6393 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Arrhythmia Section, Cardiology Department, Hospital Clínic, Universityersitat de Barcelona and bIDIBAPS, Instituteitut d’Investigació August Pi i Sunyer (IDIBAPS), Barcelona (E.A.). Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (E.A.). Search for more papers by this author , Zhengrong HuangZhengrong Huang https://orcid.org/0000-0003-0007-9321 Department of Cardiology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China (Z.H.). Search for more papers by this author , Isabelle DenjoyIsabelle Denjoy https://orcid.org/0000-0002-1786-9461 Service de Cardiologie et CNMR Maladies Cardiaques Héréditaires Rares, Hôpital Bichat, Paris and Université Paris Diderot, Sorbonne, France (I.D.). Search for more papers by this author , Carla GiustettoCarla Giustetto https://orcid.org/0000-0002-5102-3398 Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Torino, Italy (C.G., F.G.). Search for more papers by this author , Yanushi D. WijeyeratneYanushi D. Wijeyeratne https://orcid.org/0000-0003-0656-5769 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Cardiovascular Sciences, St. George’s University of London and Cardiology Clinical Academic Group St. George’s University Hospitals NHS Foundation Trust, London, UK (Y.D.W., E.R.B.). Search for more papers by this author , Andrea MazzantiAndrea Mazzanti https://orcid.org/0000-0002-0208-2172 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy (A.M.). Search for more papers by this author , Ramon BrugadaRamon Brugada https://orcid.org/0000-0001-6607-3032 Cardiovascular Genetics Center, University of Girona-IDIBGI and Medical Science Department, School of Medicine, University of Girona, Spain (R.B.). Search for more papers by this author , Ruben Casado-ArroyoRuben Casado-Arroyo Department of Cardiology, Erasme University Hospital, Universityersité Libre de Bruxelles, Belgium (R.C.-A.). Search for more papers by this author , Jean ChampagneJean Champagne https://orcid.org/0000-0001-9861-9351 Quebec Heart & Lung Institute, Quebec City, Canada (J.C.). Search for more papers by this author , Leonardo CaloLeonardo Calo https://orcid.org/0000-0002-6062-5286 Division of Cardiology, Policlinico Casilino, Roma, Italy (L.C.). Search for more papers by this author , Georgia Sarquella-BrugadaGeorgia Sarquella-Brugada https://orcid.org/0000-0002-6857-8904 Pediatric Arrhythmias, EleCentreophysiology and Sudden Death Unit Cardiology, Department Hospital Sant Joan de Déu, Barcelona - Universityersitat de Barcelona, Spain (G.S.-B.). Search for more papers by this author , Jacob Tfelt-HansenJacob Tfelt-Hansen European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). The Heart Centre, Copenhagen University Hospital and Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark (J.T.-H.). Search for more papers by this author , Silvia G. PrioriSilvia G. Priori https://orcid.org/0000-0001-6877-0288 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Search for more papers by this author , Masahiko TakagiMasahiko Takagi https://orcid.org/0000-0001-7712-8529 Division of Cardiac Arrhythmia, Kansai Medical University Medical Centre, Moriguchi, Japan (M.T.). Search for more papers by this author , Christian VeltmannChristian Veltmann https://orcid.org/0000-0001-7587-1124 Hannover Heart Rhythm Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany (C.V.). Search for more papers by this author , Pietro DelisePietro Delise https://orcid.org/0000-0001-7190-4830 Division of Cardiology, Hospital of Peschiera del Garda, Veneto (P.D.). Search for more papers by this author , Domenico CorradoDomenico Corrado https://orcid.org/0000-0003-1487-0392 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Department of Cardiac, Thoracic & Vascular Sciences University of Padova, Italy (D.C.). Search for more papers by this author , Elijah R. BehrElijah R. Behr https://orcid.org/0000-0002-8731-2853 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Cardiovascular Sciences, St. George’s University of London and Cardiology Clinical Academic Group St. George’s University Hospitals NHS Foundation Trust, London, UK (Y.D.W., E.R.B.). Search for more papers by this author , Fiorenzo GaitaFiorenzo Gaita European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Torino, Italy (C.G., F.G.). Search for more papers by this author , Gan-Xin YanGan-Xin Yan https://orcid.org/0000-0002-3118-5680 Lankenau Medical Centre, Wynnewood, PA (G.X.Y.). Search for more papers by this author , Josep BrugadaJosep Brugada https://orcid.org/0000-0002-5662-8302 Search for more papers by this author , Antoine LeenhardtAntoine Leenhardt https://orcid.org/0000-0001-7368-4528 Search for more papers by this author , Arthur A.M. WildeArthur A.M. Wilde https://orcid.org/0000-0002-0528-0852 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Amsterdam UMC, University of Amsterdam, Heart Centre and Department of Clinical and Experimental Cardiology, Amsterdam, the Netherlands (P.G.P., Y.M., A.A.M.W.). Search for more papers by this author , Pedro BrugadaPedro Brugada https://orcid.org/0000-0003-3172-6106 Heart Rhythm Management Centre, UZ-VUB, Brussels, Belgium (G.C., P.B.). Search for more papers by this author , Kengo F. KusanoKengo F. Kusano Search for more papers by this author , Kenzo HiraoKenzo Hirao Heart Rhythm Centre, Tokyo Medical and Dental University, Tokyo (S.M., Y.T., K.H.). Search for more papers by this author , Gi-Byoung NamGi-Byoung Nam https://orcid.org/0000-0003-4391-5406 Division of Cardiology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea (Gi-Byoung Nam). Search for more papers by this author , Vincent ProbstVincent Probst https://orcid.org/0000-0002-5492-8619 European Reference Network for Rare & Low Prevalence Complex Diseases of the Heart (P.G.P., A.A., J.B.G., Y.M., E.A., Y.D.W., A.M., J.T.-H., S.G.P., D.C., E.R.B., F.G., A.A.M.W., V.P.). Service de Cardiologie, CHU de Nantes (A.A., J.B.G., V.P.). Search for more papers by this author and Bernard BelhassenBernard Belhassen https://orcid.org/0000-0002-7468-2054 Heart Institute, Hadassah University Hospital, Jerusalem, Israel (B.B.) Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (B.B.). Search for more papers by this author Originally published3 Jan 2023https://doi.org/10.1161/CIRCEP.122.011360Circulation: Arrhythmia and Electrophysiology. 2023;16FootnotesFor Sources of Funding and Disclosures, see page 64.Correspondence to: Anat Milman, MD PhD, Davidai Arrhythmia Center, Leviev Heart Center Sheba Medical Center, Tel Hashomer 5265601, Israel. Email [email protected]comReferences1. Nagayama T, Nagase S, Kamakura T, Wada M, Ishibashi K, Inoue YY, Miyamoto K, Noda T, Aiba T, Takaki HT, et al. Clinical and electrocardiographic differences in Brugada syndrome with spontaneous or drug-induced type 1 electrocardiogram.Circ J. 2019; 83:532–539. doi: 10.1253/circj.cj-18-0643CrossrefMedlineGoogle Scholar2. Milman A, Gourraud JB, Andorin A, Postema PG, Sacher F, Mabo P, Conte G, Giustetto C, Sarquella-Brugada G, Hochstadt A, et al. Gender differences in patients with Brugada syndrome and arrhythmic events: data from a survey on arrhythmic events in 678 patients.Heart Rhythm. 2018; 15:1457–1465. doi: 10.1016/j.hrthm.2018.06.019CrossrefMedlineGoogle Scholar3. Tadros R, Nannenberg EA, Lieve KV, Škorić-Milosavljević D, Lahrouchi N, Lekanne Deprez RH, Vendrik J, Reckman YJ, Postema PG, Amin AS, et al. Yield and pitfalls of ajmaline testing in the evaluation of unexplained cardiac arrest and sudden unexplained death.J Am Coll Cardiol EP. 2017; 3:1400–1408. doi: 10.1016/j.jacep.2017.04.005CrossrefGoogle Scholar4. Milman A, Andorin A, Gourraud JB, Sacher F, Mabo P, Kim SH, Maeda S, Takahashi Y, Kamakura T, Aiba T, et al. Age of first arrhythmic event in Brugada syndrome: data from the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 patients.Circ Arrhythm Electrophysiol. 2017; 10:e005222. doi: 10.1161/CIRCEP.117.005222LinkGoogle Scholar5. Sieira J, Ciconte G, Conte G, de Asmundis C, Chierchia GB, Baltogiannis G, Di Giovanni G, Saitoh Y, Casado-Arroyo R, Juliá J, et al. Long-term prognosis of drug-induced Brugada syndrome.Heart Rhythm. 2017; 14:1427–1433. doi: 10.1016/j.hrthm.2017.04.044CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails January 2023Vol 16, Issue 1 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCEP.122.011360PMID: 36595628 Originally publishedJanuary 3, 2023 Keywordsventricular fibrillationelectrocardiographysyncopeBrugada syndromeheart arrestPDF download Advertisement SubjectsSudden Cardiac Death