Anaesthetic and peri-operative management for thrombectomy procedures in stroke patients

Purpose: To provide recommendations for the anaesthetic and peri-operative management for thrombectomy procedure in stroke patients Design: A consensus committee of 15 experts issued from the French Society of Anaesthesia and Intensive Care Medicine (SocieteFranc , aise d'Anesthesie et Reanimation, SFAR), the Association of French-language Neuro-Anaesthetists (Association des Neuro-Anesthesistes Reanimateurs de Langue Francaise, ANARLF), the French Neuro-Vascular Society (SocieteFrancaise de Neuro-Vasculaire, SFNV), the French Neuro-Radiology Society (SocieteFrancaise de Neuro-Radiologie, SFNR) and the French Study Group on Haemostasis and Thrombosis (Groupe Franc , ais d'E acute accent tudes sur l'Hemostase et la Thrombose, GFHT) was convened, under the supervision of two expert coordinators from the SFAR and the ANARLF. A formal conflict-of-interest policy was developed at the outset of the process and enforced throughout. The entire guideline elaboration process was conducted independently of any industry funding. The authors were required to follow the principles of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to guide their assessment of quality of evidence. Methods: Four fields were defined prior to the literature search: (1) Peri-procedural management, (2) Prevention and management of secondary brain injuries, (3) Management of antiplatelet and anticoagulant treatments, (4) Post-procedural management and orientation of the patient. Questions were formulated using the PICO format (Population, Intervention, Comparison, and Outcomes) and updated as needed. Analysis of the literature was then conducted and the recommendations were formulated according to the GRADE methodology. Results: The SFAR/ANARLF/SFNV/SFNR/GFHT guideline panel drew up 18 recommendations regarding anaesthetic management of mechanical thrombectomy procedures. Due to a lack of data in the literature allowing to conclude with high certainty on relevant clinical outcomes, the experts decided to formulate these guidelines as "Professional Practice Recommendations" (PPR) rather than "Formalized Expert Recommendations". After two rounds of rating and several amendments, a strong agreement was reached on 100% of the recommendations. No recommendation could be formulated for two questions. Conclusions: Strong agreement among experts was reached to provide a sizable number of recommendations aimed at optimising anaesthetic management for thrombectomy in patients suffering from stroke. (c) 2022 The Author(s). Published by Elsevier Masson SAS on behalf of Societefranc , aise d'anesthesie et de reanimation (Sfar). This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).