Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study.

Si Fang,James Yarmolinsky,Dipender Gill,Caroline J Bull,Claire M Perks,George Davey Smith,Tom R Gaunt,Tom G Richardson

PLoS medicine（2023）

引用 6|浏览23

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摘要

Our study supports a strong association between genetically proxied inhibition of PCSK9 and a lower risk of total and early-onset PrCa, potentially through an alternative mechanism other than the on-target effect on LDL-c. Further evidence from clinical studies is needed to confirm this finding as well as the putative mediatory role of Lp(a).

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