Apolipoprotein A-IV restrains fat accumulation in skeletal and myocardial muscles by inhibiting lipogenesis and activating PI3K-AKT signalling.

Wenqian Zhang,Xiao-Huan Liu,Jin-Ting Zhou, Cheng Cheng,Jing Xu,Jun Yu,Xiaoming Li

Archives of physiology and biochemistry（2023）

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摘要

We find that ApoA-IV reduces fat accumulation by suppressing lipogenesis and improves glucose uptake in SKM and the myocardium by regulating the PI3K-AKT pathway.

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关键词

Apolipoprotein A-IV,insulin resistance,lipid metabolism,myocardium,obesity,skeletal muscle

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