Epigenetic regulator KDM4A activates Notch1-NICD-dependent signaling to drive tumorigenesis and metastasis in breast cancer

Jing Pei,ShengQuan Zhang,Xiaowei Yang,Chunguang Han,Yubo Pan,Jun Li,Zhaorui Wang,Chenyu Sun,Jing Zhang

Translational Oncology（2023）

引用 3|浏览7

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摘要

•KDM4A potentiates BRCA progression and metastasis.•KDM4A activates Notch1 by demethylasing H3K9me3.•Targeting Notch1 using specific LY3039478 could efficiently suppress cell growth and colony formation abilities of KDM4Ahigh BRCA.

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关键词

KDM4A,Notch1,Epigenetic remodeling,Progression,Breast cancer

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