The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus.
Frontiers in immunology(2022)
摘要
We identified the extrafollicular pathway as a key contributor to autoimmune progression. We propose that therapeutic targeting of low quality and poorly controlled extrafollicular responses could be a desirable strategy to curb autoreactivity, as it would leave intact the more stringently controlled and high-quality GC responses providing durable protection against infection.
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关键词
B cells,TLR7,autoantibodies,autoimmunity,extrafollicular responses,germinal centers,systemic lupus erythematosus
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