Reliability of CD44, CD24, and ALDH1A1 immunohistochemical staining: Pathologist assessment compared to quantitative image analysis.

Lusine Yaghjyan,Yujing J Heng,Gabrielle M Baker,Vanessa Bret-Mounet,Divya Murthy,Matt B Mahoney,Yi Mu,Bernard Rosner,Rulla M Tamimi

Frontiers in medicine（2022）

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摘要

Our findings show that computational assessments for CD44, CD24, and ALDH1A1 exhibit variable correlations with manual assessment. These findings support the use of computational platforms for IHC evaluation of stem cell markers in large-scale epidemiologic studies. Pilot studies maybe also needed to determine appropriate cut-offs for defining staining positivity.

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关键词

automated image analysis,benign breast disease (BBD),immunohistochemistry,intra-class correlation (ICC),stem cell markers

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