DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

Martin Gerhards,Alexander Böhme,Kristin Schubert, Bernhard Kodritsch,Nadin Ulrich

Current Research in Toxicology（2023）

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摘要

•Link between DNA adducts and BaP exposure.•Strategy for quantitative in vitro-in vivo extrapolation for carcinogen BaP.•Discussion of problems in quantitative in vitro-in vivo extrapolation.

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关键词

In vitro-in vivo extrapolation IVIVE,Benzo[a]pyrene,DNA adduct formation

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