Water extract of Notopterygium incisum alleviates cold allodynia in neuropathic pain by regulation of TRPA1

Yonglan Ruan,Xiang Jin,Haiwang Ji,Chan Zhu,Yan Yang,Yuan Zhou,Guang Yu,Changming Wang,Zongxiang Tang

Journal of Ethnopharmacology（2023）

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摘要

•WN reduced cold pain and allyl isothiocyanate (AITC, Transient Receptor Potential A1 (TRPA1 agonist)) induced pain by inhibiting TRPA1 directly.•WN reduced chronic constriction injury (CCI) and cisplatin induced cold allodynia in neuropathic pain by inhibiting TRPA1.

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关键词

Notopterygium incisum,Cold pain,Neuropathic pain,DRG,TRPA1

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