Antimicrobial activity of water-soluble tetra-cationic porphyrins on Pseudomonas aeruginosa

Carolina Gonzalez Urquhart,Ticiane da Rosa Pinheiro,Jean Lucas Gutknecht da Silva,Daniela Bitencourt Rosa Leal,Thiago Augusto Lima Burgo,Bernardo Almeida Iglesias,Roberto Christ Vianna Santos

Photodiagnosis and Photodynamic Therapy（2023）

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摘要

•Use of water-soluble tetra-cationic porphyrins against Gram-negative bacteria.•Antimicrobial and a preliminary antibiofilm activity against Pseudomonas aeruginosa.•The water-soluble tetra-cationic porphyrin 4-H2TMePor is highly effective in photoinactivating PA01.•4-H2TMePor was not cytotoxic against human keratinocytes and fibroblasts.

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关键词

Gram-negative,Checkerboard,Antibiofilm activity,Photoinactivation,Photodynamic therapy

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