Chalcone Derivatives Suppress Proliferation and Migration of Castration-resistant Prostate Cancer Cells Through FAK-mediated DNA Damage.

Hainiao Xiao,Zhigang Wu,Qinquan Wang,Chaofeng Zhou, Feng Lu,Yunbei Xiao

Anticancer research（2023）

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摘要

We discovered two chalcone derivatives and collective results indicated that inhibited CRPC cell proliferation and migration through FAK-mediated DNA damage and may be a potential therapeutic drug against CRPC.

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关键词

Castration-resistant prostate cancer,DNA damage,chalcone derivative,focal adhesion kinase,migration,proliferation

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