SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis

Journal of Advanced Research（2023）

引用 9|浏览30

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摘要

Hyperlipidemia-associated cytokines and disturbed flow upregulate SOX4 expression in ECs, where SOX4 promotes EndoMT and atherogenesis. Metformin pharmacologically suppresses SOX4 level in ECs. EC, endothelial cell; IL-1β, interleukin-1β; TGF-β1, transforming growth factor β1.

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关键词

Atherosclerosis,EndoMT,Endothelial cells,Shear stress,Single-cell RNA sequencing

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