Contraceptive failure and sugammadex administration: a single centre survey and audit of professional knowledge and practice.

Editor—While the global popularity of sugammadex continues to rise, 1 Hunter J.M. Reversal of neuromuscular block. BJA Educ. 2020; 20: 259-265 Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar anaesthetists' knowledge and management of an important potential interaction may have failed to keep pace. 2 Dalton J. Van Hasselt G. Sugammadex – time of onset; nine months. Anaesthesia. 2016; 71: 115-116 Crossref PubMed Scopus (8) Google Scholar Studies in vitro using isothermal microcalorimetry have identified high binding affinity of sugammadex for steroidal hormones, notably progesterone. 3 European Medicines Agency. Evaluation of medicines for human use: assessment report for Bridion. Doc. Ref: EMEA/CHMP/317523/2008. Available from: https://www.ema.europa.eu/en/documents/assessment-report/bridion-epar-public-assessment-report_en.pdf (accessed 1 July 2022). Google Scholar As the active component of many hormonal contraceptives, in vivo inactivation of progesterone by sugammadex could therefore temporarily cause contraceptive failure, exposing women to the risk of unplanned pregnancy. 4 Bridion Prescribing Information. Available from: https://www.merck.com/product/usa/pi_circulars/b/bridion/bridion_pi.pdf (accessed 10 June 2022). Google Scholar