Small Molecule-mediated Disruption of Ribosome Biogenesis Synergizes With FGFR Inhibitors to Suppress Glioma Cell Growth.

Asimina Zisi,Dimitris C Kanellis,Simon Moussaud,Ida Karlsson,Helena Carén,Lars Bräutigam,Jiri Bartek,Mikael S Lindström

Neuro-oncology（2022）

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摘要

This study conceptualizes the implementation of RiBi inhibition as a viable future therapeutic strategy for glioma and reveals an FGFR connection to the cellular response upon RiBi inhibition with potential translational value.

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关键词

Combination therapy,FGFR1/FGF2 signaling,Glioblastoma,RNA polymerase I,Ribosome biogenesis

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