Systemic blockade of proBDNF inhibited the expansion and altered the transcriptomic expression in CD3 + B220 + cells in MRL/lpr lupus mice.

An-Hui Zha,Cong Luo,Wei-Yun Shen,Di Fu,Ru-Ping Dai

Lupus science & medicine（2022）

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摘要

Systemic blockade of proBDNF inhibited the overexpansion of CD3B220 cells and altered their signals related to cell cycle, cell apoptosis and the immune response, which may contribute to the attenuation of disease symptoms in murine lupus.

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关键词

autoimmune diseases,autoimmunity,lupus erythematosus, systemic

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