Solubilized curcuminoid complex prevents extensive immunosuppression through immune restoration and antioxidant activity: Therapeutic potential against SARS-CoV-2 (COVID-19)

•CTX-treated animals had fewer activation of innate and adaptive immune cells.•CS/M restores suppressed innate cell activations observed in CTX-induced immunosuppression.•CTX-injected mice pre-exposed to CS/M encourages the immuno-enhancing effects for Th1, CTL, and multifunctional T cell responses.•CTX-injected mice pre-exposed to CS/M increased antioxidant enzymes.•CS/M significantly reduced viral loads in SARS-CoV-2-infected hamsters.