CYP2C9 gene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study.

Irina I Sinitsina,Alexey V Boyarko,Ilyas I Temirbulatov,Dmitry A Sychev,Kristina A Akmalova,Zhannet A Sozaeva,Elena A Grishina,Karin B Mirzaev,Anastasiia V Asoskova,Vladimir P Fisenko

Drug metabolism and personalized therapy（2022）

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摘要

Carriage of low function polymorphic variants of the gene ( and ) reduced the hypotensive effect of losartan according to ABPM and don't affect uric acid level in plasma and E-3174/losartan in urine.

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关键词

CYP2C9 ,APBM,E-3174,losartan,polymorphisms,uric acid

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