Lipocalin 2, synthesized using a cell-free protein synthesis system and encapsulated into liposomes, inhibits the adhesion of Porphyromonas gingivalis to human oral epithelial cells.

Jun-Ichi Kido,Yuka Hiroshima,Rie Kido,Kaya Yoshida,Yuji Inagaki,Koji Naruishi,Kazuaki Kajimoto,Masatoshi Kataoka, Yasuo Shinohara,Hiromichi Yumoto

Journal of periodontal research（2023）

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摘要

LCN2 was artificially synthesized by a CFPS system, encapsulated in liposomes, and delivered to oral epithelial cells, and demonstrated an antibacterial action against P. gingivalis. This approach may become a useful model for oral healthcare.

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关键词

Lipocalin 2,antimicrobial peptide,cell-free protein synthesis,drug delivery system,liposome,oral epithelial cells,oral healthcare

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