Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling.

Aman George,Jerry Lee,James Liu,Suzie Kim,Brian P Brooks

Developmental dynamics : an official publication of the American Association of Anatomists（2023）

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摘要

Zebrafish rerea mutants exhibit OS and optic fissure closure defects. The optic fissure closure defect was rescued by an shh signaling inhibitor, suggesting that this defect could arise due to deregulated shh signaling.

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关键词

RERE and SHH,coloboma,optic fissure,optic stalk

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