Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions in Malaria-Hyperendemic Region, South Sudan.

Irene Molina-de la Fuente,María José Sagrado Benito, Laurence Flevaud,Janet Ousley,Harriet Akello Pasquale,Ahmed Julla,Abdirashid M Abdi,Buai Tut Chol,Bakri Abubakr,Agustín Benito,Cristian Casademont,Carolina Nanclares,Pedro Berzosa

Emerging infectious diseases（2023）

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摘要

Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for pfhrp3, and 7.5% for double deletions. Deletions were approximately twice as prevalent in monoclonal infections than in polyclonal infections.

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关键词

Plasmodium falciparum,RDT,South Sudan,diagnosis,histidine-rich protein,malaria,molecular epidemiology,parasites,surveillance,vector-borne infections

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