Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway
Journal of Asian natural products research(2023)
摘要
Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO2 cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.
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关键词
AKT,ECH,T2DM,glucose,insulin resistance
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