Depression and Anxiety on Twitter During the COVID-19 Stay-At-Home Period in 7 Major U.S. Cities

•Twitter depression and anxiety scores were elevated across 7 U.S. cities.•Twitter depression trends were aligned with national COVID-19 case trends.•Twitter anxiety trends were consistently elevated throughout the pandemic.•Google search trends data showed noisy and inconsistent results.•Twitter can supplement surveys to assess psychological well-being in populations.