Upfront BRAF/MEK inhibitors for treatment of high-grade glioma: A case report and review of the literature.

Gabrielle Arbour,Benjamin Ellezam,Alexander G Weil,Romain Cayrol,Magimairajan Issai Vanan,Hallie Coltin,Valérie Larouche,Craig Erker,Nada Jabado,Sébastien Perreault

Neuro-oncology advances（2022）

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摘要

Our patient had durable disease control with dabrafenib and trametinib. Given favorable responses reported in patients with HGG treated with BRAF inhibitors, we believe that upfront targeted therapy is a possible treatment approach that should be studied in the context of a clinical trial.

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关键词

BRAF V600E,BRAF inhibitors,MEK inhibitors,high-grade glioma

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