Mucin 1 downregulation decreases the anti-tumor effects of melanoma vaccine.

Annals of translational medicine(2022)

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摘要
MUC1 has strong melanoma vaccine immunogenicity, and induces the host's anti-tumor reaction. knockdown inhibits the immune activity of B16F10 cell vaccine and anti-melanoma effect, suggesting the MUC1 is an important candidate target antigen of the melanoma vaccine.
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关键词
Melanoma,melanoma vaccine,mucin 1 (MUC1),target antigen,vaccination
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