BDNF/TrkB confers bortezomib resistance in multiple myeloma by inducing BRINP3

Li Bao,Yutong Wang,Minqiu Lu,Lei Shi,Bin Chu,Shan Gao

Biochimica et Biophysica Acta (BBA) - General Subjects（2023）

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摘要

•BDNF/TrkB signaling pathway mediated the BTZ resistance of MM.•Overexpression of BRINP3 significantly reversed BDNF/TrkB-mediated MM cell proliferation.•BDNF/TrkB may be a potential target for treatment of BTZ-resistant MM.

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关键词

Multiple myeloma,Bortezomib resistance,BDNF,TrkB,BRINP3

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