Self-assembling micelles of lipopolysaccharides (LPS) for loading hydrophobic (bio)molecules

Mariana A. Noronha,Natália A. D'Angelo,Germán Pérez-Sánchez,Patrícia Severino,Mary Ann Foglio,Tamar L. Greaves,Jorge F. B. Pereira,André M. Lopes

Journal of Molecular Liquids（2023）

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摘要

•Different (bio)molecules (i.e., chloroquine, curcumin, vemurafenib, and doxorubicin) can be encapsulated into LPS-based micelles.•LPS micelle size is highly dependent on the interaction of the (bio)molecules.•LPS concentrations close to or above the CMC result in the formation of LPS micelles with a significant size variation.•LPS-based micelles and their interaction with (bio)molecules could lead to novel applications in nanobiotechnology.

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关键词

Lipopolysaccharides (LPS),Nanostructures,Micelles,Drug encapsulation,Critical micelle concentration (CMC),Self-assembly

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