EP177/#433 Patterns of care and outcomes for endometrial and ovarian cancers in Botswana 2015–2021

Objectives

Endometrial and ovarian cancers are leading causes of cancer death among women globally. However, there is little published data on patterns of care and outcomes on these patients from low- and middle-income countries including Botswana, a country in sub-Saharan Africa. We describe and analyze patterns of care and outcomes for a cohort of ovarian and endometrial cancer patients in Botswana.

Methods

This study included all patients with endometrial or ovarian cancer who presented to Princess Marina or Gaborone Private Hospital between May 2015 and May 2021. Demographic, treatment, and survival data were analyzed.

Results

99 endometrial and 38 ovarian cancer patients were included. Median age at diagnosis was 64 (IQR 58.5–70) for endometrial cancer patients and 57 (IQR 50–69.5) for ovarian cancer patients. Just over half of endometrial cancer patients (n=52, 52.6%) presented with FIGO stages I and II, whereas most ovarian cancer patients (n=25, 65.8%) presented with stages III and IV. 23.2% (n=23) of endometrial cancer patients received chemotherapy, 29.3% (n=29) received radiotherapy, and 61.6% (n=61) received surgical treatment; of ovarian patients, 42.1% (n=16) received chemotherapy, 5.3% (n=2) received radiotherapy, and 47.4% (n=18) received surgical treatment. 1-and 2-year overall survival probabilities were 76.9% and 59.7% for endometrial cancer patients and 62.8% and 43.7% for ovarian cancer patients, respectively.

Conclusions

Our results suggest that survival outcomes for patients with ovarian and endometrial cancer in Botswana are far worse than those in the United States, likely due to late stage presentation and challenges in care delivery.