Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus.

Hannah Swahn, Kun Li,Tomas Duffy,Merissa Olmer,Darryl D D'Lima,Tony S Mondala,Padmaja Natarajan,Steven R Head,Martin K Lotz

Annals of the rheumatic diseases（2023）

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摘要

These single-cell studies identified a senescent pathogenic cell cluster that is present in cartilage and meniscus and has FAP and ZEB1 as main regulators which are novel and promising therapeutic targets for OA-associated pathways in both tissues.

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arthritis,chondrocytes,osteoarthritis

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