Using Tumor-Informed Circulating Tumor DNA (ctDNA)-Based Testing for Patients with Anal Squamous Cell Carcinoma.

Georges Azzi,Mehrad Tavallai,Vasily N Aushev,Allyson Koyen Malashevich,Gregory P Botta,Mohamedtaki A Tejani,Diana Hanna,Shifra Krinshpun,Meenakshi Malhotra,Adham Jurdi,Alexey Aleshin,Pashtoon M Kasi

The oncologist（2023）

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摘要

Our study demonstrates the feasibility of personalized and tumor-informed ctDNA testing as an adjunctive tool in patients with SCCA as well as potential use for detection of molecular/minuteimal residual disease, and relapse during surveillance. Prospective studies are needed to better evaluate the use of ctDNA testing in this indication.

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关键词

anal squamous cell carcinoma,circulating tumor DNA,minimal/molecular residual disease,prognostic biomarker

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