The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets.

Gaofeng Li, Qiru Fu,Cong Liu, Yuxi Peng,Jun Gong, Shilan Li,Yan Huang,Haiyuan Zhang

Frontiers in oncology(2022)

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摘要
N6-methyladenosinen (mA) methylation is a frequent RNA methylation modification that is regulated by three proteins: "writers", "erasers", and "readers". The mA modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked mA RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of mA RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of mA RNA modification in GC.
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关键词
RNA methylation,gastric cancer,m6A RNA modification,mRNA,ncRNA
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