Efficacy identification and active compounds screening of topically administration of Scutellaria Radix in oral ulcer

•·Firstly certified that topical administrated Scutellaria Radix alone in oral cavity can treat oral ulcer.•·GRA, PLSR, and “spider-web” mode were used in spectrum-effect analysis.•·Potential compounds was validated alone and in combination, and compared to the overall drug efficacy.•·Baicalin, baicalein, and wogonoside were able to treat oral ulcer by topically administration.