Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study.

Craig Erker,Martin Mynarek,Simon Bailey, Claire M Mazewski,Lorena Baroni,Maura Massimino,Juliette Hukin,Dolly Aguilera,Andrea M Cappellano,Vijay Ramaswamy,Alvaro Lassaletta,Sébastien Perreault,Cassie N Kline,Revathi Rajagopal,George Michaiel,Michal Zapotocky,Vicente Santa-Maria Lopez,Andres Morales La Madrid,Chantel Cacciotti,Eric S Sandler,Lindsey M Hoffman,Darren Klawinski,Sara Khan,Ralph Salloum,Anna L Hoppmann,Valérie Larouche,Kathleen Dorris,Helen Toledano,Stephen W Gilheeney,Mohamed S Abdelbaki,Beverly Wilson,Derek S Tsang,Jeffrey Knipstein,Michal Yalon Oren,Shafqat Shah,Jeffrey C Murray,Kevin F Ginn, Zhihong J Wang,Gudrun Fleischhack,Denise Obrecht,Svenja Tonn,Virginia L Harrod,Kara Matheson,Bruce Crooks,Douglas R Strother,Kenneth J Cohen,Jordan R Hansford,Sabine Mueller,Ashley Margol,Amar Gajjar,Girish Dhall,Jonathan L Finlay,Paul A Northcott,Stefan Rutkowski,Steven C Clifford,Giles Robinson,Eric Bouffet,Lucie Lafay-Cousin

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

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摘要

A substantial proportion of patients with relapsed iMB are salvaged after initial CSI-sparing approaches. Patients with SHH subgroup, localized relapse, older age at initial diagnosis, and those receiving salvage CSI show improved PRS. Future prospective studies should investigate optimal CSI doses and the role of salvage chemotherapy in this population.

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