NDRG1 Signaling is Essential for Endothelial Inflammation and Vascular Remodeling.

Guanxin Zhang,Qing Qin,Chen Zhang,Xiaobo Sun,Kyosuke Kazama,Bing Yi,Fang Cheng,Zhi-Fu Guo,Jianxin Sun

Circulation research（2022）

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摘要

Our results for the first time identify NDRG1 as a critical mediator implicated in regulating endothelial inflammation, thrombotic responses, and vascular remodeling, and suggest that inhibition of NDRG1 may represent a novel therapeutic strategy for inflammatory vascular diseases, such as atherothrombosis and restenosis.

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关键词

AP-1, Nur77,NDRG1,NF-κB,endothelial cells,inflammation

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